Registry fixes alone are often insufficient on Windows 10/11. The following components must be addressed alongside registry modification.
This is a issue. Right-click pes6.exe → Properties → Compatibility: pes 6 registry 64 bit install
For 64-bit versions of Windows (like Windows 7, 10, or 11), the game's settings are stored here: HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\KONAMIPES6\PES6 Manual Registry Setup Registry fixes alone are often insufficient on Windows 10/11