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The dosing guidelines for MMS vary and are often described in terms of "drops" of MMS mixed with water. A common protocol might start with a low dose (e.g., 1-2 drops of MMS activated with 1/4 teaspoon of citric acid in 4 ounces of water) taken once or twice a day, gradually increasing the dose based on individual tolerance. However, these guidelines are not universally agreed upon, and there is no standard protocol.

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The majority of evidence supporting MMS is anecdotal. Mainstream science and health organizations do not support the use of MMS for the treatment of any disease due to a lack of clinical trials and evidence.