At its core, the film is a meditation on the human impulse toward self-destruction , a concept distinct from suicide. As Dr. Ventress explains, while few choose to end their lives, almost everyone engages in self-destructive behaviors—sabotaging stable marriages, ruining careers, or engaging in health-compromising habits.
The film begins with a flashback to a canoeing accident that resulted in the death of a biologist, Lena's (Natalie Portman) husband, Kane (Oscar Isaac). Shortly after, Lena encounters a strange, glowing entity while on a military mission. This encounter leads her to join an expedition, led by the resolute and calm Dr. Ventress (Jennifer Jason Leigh), into the mysterious "Shimmer," where previous expeditions have mysteriously disappeared. i annihilation 2018 mm submp4 work work