Technically, yes. Practically, no. Deleting it will cause the game to constantly look for missing files. If you must save space, move the folder to an external drive. Deleting it can cause infinite loading screens during winter events or when joining modded servers.
: Sometimes an automatic update fails to verify this specific sub-folder, leaving it stuck on an older version that isn't compatible with the current GTA5.exe . How to Update the Mpchristmas2017 Dlc.rpf Update X64 Dlcpacks Mpchristmas2017 Dlc.rpf
The game loads to 90% and then crashes, or you receive a ERR_FIL_PACK_1 error. Cause: A mod was improperly installed into the mpchristmas2017 archive, or the archive was not rebuilt correctly after editing. Technically, yes