Go to [PES 2021 install folder]/_CommonRedist/DirectX/Jun2010/ and run DXSETUP.exe . Even if you think you have DirectX up to date, this fixed the silent crash for me.
: You can bypass the executable entirely by downloading a pre-configured settings.dat file and placing it in your save folder (typically Documents\KONAMI\eFootball PES 2021 SEASON UPDATE\ ).
Restart your PC after installation and try opening the file again. 2. Manage Windows Security & Ransomware Protection Windows often flags settings.exe as a threat because it tries to modify files in your Add an Exclusion
This is a weird but famous fix for PES. The Settings app sometimes fails if your system language is not fully supported.